Endocrine Abstracts

Epigenetic events, such as gene promoter DNA hypermethylation linked to changes in gene expression, are causative of resistance to cytotoxic chemotherapy drugs such as cisplatin in ovarian cancer cell line models, and associated with response to chemotherapy and survival of high grade serous ovarian cancer patients. We are studying the role of epigenetic change throughout the patient journey and how this associates with gene expression changes which can be selected for during ...

Introduction: Hyperinsulinaemic hypoglycaemia (HH) is the most common cause of severe and persistent hypoglycaemia in neonates. The treatment of diazoxide unresponsive HH involves pancreatectomy. Mammalian target of rapamycin (mTOR) is a protein kinase that regulates cellular proliferation. We aimed to evaluate the efficacy of mTOR inhibitor Sirolimus and assess mTOR expression in the pancreas of infants with severe HH.Methods: Four infants with severe, ...